Identification of functions related to oral bacteria colonization

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21384
• Project/Area Number (Other): 18H06296 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0907:Oral science and related fields
• Research Institution: Kyushu University
• Principal Investigator: Kageyama Shinya 九州大学, 歯学研究院, 助教 (90822495)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 乳幼児 / 口腔マイクロバイオーム / 定着 / 成熟 / 16S rRNA / ロングリードシークエンサー

Outline of Final Research Achievements

In this study, we found that drastic compositional shifts in oral microbiota occurred by the age of 2 years and bacterial diversity and overall bacterial composition reached levels comparable to those in adults. We also found bacterial strains that belonged to same species but showed quite different behavior in these period. These results may be helpful for elucidation of colonization mechanism of oral bacteria and preventing the development of various diseases associated with oral microbiota throughout life.

Free Research Field

予防歯科学

Academic Significance and Societal Importance of the Research Achievements

口腔マイクロバイオームが全身の健康に大きく影響することから、常在細菌定着のメカニズムを明らかにし、マイクロバイオーム形成を制御・誘導することで、疾患発症を予防することができると考えられる。本研究の結果は、常在細菌定着のメカニズム解明の基盤となり、口腔マイクロバイオームをターゲットにした新たな治療法の開発につながる点で社会的意義は大きい。