Development of next generation bioactive root canal treatment that activates immune response and bone metabolism

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21409
• Project/Area Number (Other): 18H06325 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0907:Oral science and related fields
• Research Institution: Osaka University
• Principal Investigator: Naruse Haruna 大阪大学, 歯学部附属病院, 医員 (60823515)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 根管貼薬材 / Wntシグナル経路

Outline of Final Research Achievements

Recently, various disease-related genes have been identified by single nucleotide polymorphism (SNP).Previous studies have found that the Wnt signaling pathway, which plays a crucial role in bone remodeling, is a disease-related gene for apical periodontitis in Japanese. In this study, in order to investigate the mechanism, we analyzed lithium chloride (LiCl), which activates the Wnt signaling pathway, as a root canal patch in a model animal with apical periodontitis. It was revealed that the LiCl group promoted healing of apical lesions and activation of immunity compared with the control group. In the future, based on the results of this study, we hope that LiCl has potential as a novel therapeutic substance for periapical periodontitis by activating the Wnt signaling pathway.

Free Research Field

歯内療法学

Academic Significance and Societal Importance of the Research Achievements

本研究では、Wnt シグナル伝達経路を活性化するリチウムクロライド（LiCl）を根管貼薬剤として根尖性歯周炎モデル動物を用いて解析したところ、根尖病変の治癒の促進および免疫の賦活化も生じていることが明らかとなった。現在の根管貼薬剤では殺菌を行うものばかりであるが、根尖病変自体の治癒を促す根管貼薬剤をいうものは存在しない。本研究の成果をもとにして、バイオアクティブな次世代根管貼薬剤の開発につなげていきたい。