Establishment of a new biomarker to assess the short-term effects of exercise - application of mitohormesis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K21427
• Project/Area Number (Other): 18H06344 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0908:Society medicine, nursing, and related fields
• Research Institution: Kochi University (2020); Okayama University (2018-2019)
• Principal Investigator: Ogino Shihona 高知大学, 医学部, 客員助教 (70746685)
• Project Period (FY): 2018-08-24 – 2021-03-31
• Keywords: 運動療法 / 予防医学 / 酸化ストレス / ミトコンドリア

Outline of Final Research Achievements

Results of an exercise intervention study in 14 volunteers conducted at Kochi University showed that several antioxidant enzymes (SOD1, SOD2 and GPX1) in blood cells were significantly increased by exercise training for two weeks. In addition, a cross-sectional study of 392 healthy adults visiting a health check-up found that SOD2 in blood cells was an independent predictor of exercise habits in non-smokers. The results were presented at the KMS-Research Meeting in February 2021 and the 91st Annual Meeting of the Japanese Society for Hygiene in March 2021, and were accepted for publication in the international journal JCBN.

Free Research Field

予防医学

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、運動がもたらす健康増進の機序の一つであるミトコンドリア機能の上昇が、筋組織だけでなく血球でも起きている可能性を見出したものである。従来、運動の効果は、数ヶ月の継続によって得られる血圧の低下や耐糖能の改善が指標とされていた。本研究で見出された血球中のSOD2のmRNAの相対量は、比較的短期間の運動で上昇し、採血検体から評価が可能であることから、運動習慣を定着させるための動機付けの簡易な指標として有用である可能性がある。