2019 Fiscal Year Final Research Report
Investigation of carcinogenic factors of occupational bladder cancer occurred at a chemical factory handling aromatic amines
Project/Area Number |
19K21430
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Project/Area Number (Other) |
18H06347 (2018)
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund (2019) Single-year Grants (2018) |
Review Section |
0908:Society medicine, nursing, and related fields
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Research Institution | Osaka City University |
Principal Investigator |
Yukimatsu Nao 大阪市立大学, 大学院医学研究科, 医員 (50823572)
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Project Period (FY) |
2018-08-24 – 2020-03-31
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Keywords | 芳香族アミン / 膀胱発がん / 職業性膀胱がん / AAOT / OTD |
Outline of Final Research Achievements |
In the present study, we aimed to evaluate the effects of aromatic amine acetoaceto-o-toluidide (AAOT) on urinary bladder carcinogenesis and the mechanisms of AAOT-mediated carcinogenicity.The results of the present studies demonstrate that AAOT, like other carcinogenic aromatic amines, is carcinogenic to the urinary bladder. Overexpressed of JUN and its downstream target genes involve the bladder carcinogenicity of AAOT, and o-toluidine (OTD), a known bladder carcinogen metabolized from AAOT, is the ultimate bladder carcinogen of AAOT.
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Free Research Field |
膀胱発がん
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Academic Significance and Societal Importance of the Research Achievements |
芳香族アミンによる職業性膀胱発がんはよく知られているが、acetoaceto-o-toluidide (AAOT) の膀胱発がん性についてはほとんど知られていない。本研究では、AAOTが他の芳香族アミンと同様に膀胱発がん物質であることを初めて明らかにした。AAOTの膀胱発がん性及びメカニズムを公開したことは、社会的意義が高く、芳香族アミンによる膀胱発がんの知見を深めることに貢献したと考える。
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