2018 Fiscal Year Annual Research Report
Flavonoid intake in the Japanese population and its effect on the the development of cardiovascular disease
| Project/Area Number |
18H06391
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| Allocation Type | Single-year Grants |
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| Research Institution | Osaka University |
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Principal Investigator |
董 加毅 大阪大学, 医学系研究科, 特任研究員 (90823625)
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | flavonoid / cardiovascular disease / cohort study / preventive medicine / fruit |
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| Outline of Annual Research Achievements |
1. We have estimated the flavonoid intake among the Japanese population using the Phenol-Explorer database. This estimation was based on a validated semi-quantitative food-frequency questionnaire with many flavonoid-rich foods and beverages including coffee, tea, wine, soy, apple, orange, strawberry, grape, onion, broccoli, and so on.
2. We have analyzed the association between flavonoid intake and risk of cardiovascular disease using the data of a large prospective cohort study. The association between flavonoid-rich fruits (including apple, orange, grapefruits, strawberry, pear, and grape) and risk of cardiovascular disease (coronary heart disease and stroke) have also been examined.
3. We have completed a manuscript on strawberry consumption and stroke risk and will submit to international journals for publication.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The research has been carried out as planned. There has been no unexpected accidents.
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| Strategy for Future Research Activity |
Since we have analyzed the association between flavonoid intake and risk of cardiovascular disease as planed, the research moves forward to examine the effect of flavonoid intake on hypertension, which is one of the most important risk factor of cardiovascular disease. A meta-analysis of published cohort studies will be performed. Detailed plan is listed as below.
1. searching PubMed database for cohort studies examining a temporal relationship between flavonoid intake and risk of hypertension incidence
2. selecting potential studies and extracting data from each study
3. combining the risk estimates of individual studies by a meta-analysis
4. writing a report
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