2019 Fiscal Year Final Research Report
The investigation of patellar tendinopathy using animal models and ultrasonography
| Project/Area Number |
19K21510
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| Project/Area Number (Other) |
18H06437 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | 超音波診療 / 膝蓋腱障害 |
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| Outline of Final Research Achievements |
Ultrasound is useful for evaluation of tendon injuries and disorders. However, there is a lack of knowledge about the biological significance of the ultrasound findings. The purpose of this study was to establish a rat patellar tendon injury model and to compare ultrasound findings with tissue histological analysis. It was confirmed that the healing process of the patellar tendon resection model can be evaluated non-invasively by an ultrasound. In addition, it was confirmed that partial bone (patella and tibia) resection for patellar tendon healing had a significant influence (enlargement of residual tendon tissue and increase in regenerated tissue volume), and showed that ultrasound findings and histological features well correlated. Treadmill running load didn't affect patellar tendon tissue healing.
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| Free Research Field |
スポーツ医学、整形外科学、健康科学
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| Academic Significance and Societal Importance of the Research Achievements |
運動器超音波（エコー）の使用は今後ますます増えると予想される。腱組織は、そのターゲットとして重要であり、様々な場面でのエコーの活用が期待される。本研究の成果として、腱障害の動物疾患モデルと縦断的超音波評価を用いた実験モデルの確立があげられる。様々な外科的介入・保存的加療の基礎的知見を得るための有用なツールとなる。また、本研究の技術は筋損傷モデルや神経損傷モデルへの発展が可能であり、意義は大きい。
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