Anti-aging challenge based on chrono-nutrition

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K21597
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Studies on the Super-Aging Society
• Research Institution: Waseda University
• Principal Investigator: Shibata Shigenobu 早稲田大学, 理工学術院, 教授 (10162629)
• Co-Investigator(Kenkyū-buntansha): 田原 優 早稲田大学, 理工学術院, 准教授(任期付) (80707399)
• Project Period (FY): 2019-06-28 – 2021-03-31
• Keywords: 体内時計 / 時間制限給餌 / ミトコンドリア / 老化

Outline of Final Research Achievements

The purpose of this study was to accelerate the study by using a premature aging mouse called Polg mutant, and to investigate whether dietary time restricted feeding (TRF) is effective for longevity and aging. However, in Polg mutant mice, almost no effect of TRF could be confirmed. On the other hand, WT mice showed positive effects in grip strength and treadmill tests.
In addition, another research group in the United States conducted TRF using WT and reported in 2020 that it had a life-prolonging effect. Therefore, we considered that TRF is likely to have an effect on WT, and considered that "the anti-aging effect of TRF is not observed in Polg mutant mice because mitochondrial function is reduced."　The normal function of mitochondria is important for longevity.

Free Research Field

時間栄養学

Academic Significance and Societal Importance of the Research Achievements

Polg mutantという早期老化マウスを用いることで、食餌時刻の制限（TRF）が寿命や老化に効果的である可能性について調べた。すなわちTRFはPolg mutantマウスの寿命を延ばすこと期待した。しかしながら、対照群のワイルドに比較すると、全く効果が見られなかったので、正常なミトコンドリアこそが、抗老化に大事であることが分かった。一般的に抗酸化作用を持つ食品は寿命延長作用があると信じられているが根拠がほとんどなかった。本研究成果から、実際、ミトコンドリア機能が過酸化反応で障害を受けないようにすることが寿命延長に重要であることを社会に示すことが出来た。