The roles of basolateral amygdala in regulation of optimism and pessimism

2020 Fiscal Year Research-status Report

• Project/Area Number: 19K21807
• Research Institution: University of Tsukuba
• Principal Investigator: 張 王其 筑波大学, 人間系, 助教 (20525604)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: cognitive bias / neural circuit / retrograde tracing / single cell analysis / fiber photometry / optimism / pessimism

Outline of Annual Research Achievements

We expressed GCaMP and RCaMP in two different populations of BLA and successfully recorded the neuronal activity of the two population of cells during ambiguou cue interpretation task. Our preliminary data showed that the relative excitability of the "positve" cells and "negative" cells determines the direction of cognitive bias of experiment subjects.

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

Due to the coronovirus, we had to sacrifice part of our animals. So our sample size was not enough for the experiment of this stage.

Strategy for Future Research Activity

We will increase the sample number for calcium imaging test to arrive at a solid conclusion.

Causes of Carryover

We will need to purchase animal, packing AAV virus, consumerables for calcium imaging

Research Products

• [Journal Article] The hippocampus encodes delay and value information during delay-discounting decision making. (2021)
  • Author(s): Masuda A, Sano C, Zhang Q, Goto H, McHugh T, Fujisawa S, Itohara S.
  • Journal Title: Elife Volume: 9 Pages: 52466
  • DOI: 10.7554/eLife.52466.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] On the Origins of Diversity in Social Behavior (2021)
  • Author(s): Larry J Young, Qi Zhang
  • Journal Title: The Japanese Journal of Animal Psycholog Volume: - Pages: 1-17
  • DOI: 10.2502/janip.71.1.4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models (2021)
  • Author(s): Lenin C Kandasamy, Mina Tsukamoto, Vitaliy Banov, Sambuu Tsetsegee, Yutaro Nagasawa, Mitsuhiro Kato, Naomichi Matsumoto, Junji Takeda, Shigeyoshi Itohara, Sonoko Ogawa, Larry J Young, Qi Zhang
  • Journal Title: Human Molecular Genetics Volume: - Pages: 1-13
  • DOI: 10.1093/hmg/ddab052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] The trait-like differences in cognitive bias in outbred CD-1 mice (2021)
  • Author(s): Sambuu Tsetsegee, Vitaliy Banov, Maria Pires Fraga, Lenin C Kandasamy, Shigeyoshi Itohara, Larry J Young, Qi Zhang
  • Organizer: The 44th Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models (2021)
  • Author(s): Lenin C Kandasamy, Mina Tsukamoto, Vitaliy Banov, Sambuu Tsetsegee, Yutaro Nagasawa, Mitsuhiro Kato, Naomichi Matsumoto, Junji Takeda, Shigeyoshi Itohara, Sonoko Ogawa, Larry J Young, Qi Zhang
  • Organizer: The 44th Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] On the origin of diversity in social behavior. (2021)
  • Author(s): Larry J Young, Qi Zhang
  • Organizer: East/South East Asia Social Brain Symposium
  • Int'l Joint Research / Invited
• [Presentation] GPI protein in neuroscience and neurological diseases. (2021)
  • Author(s): Qi Zhang
  • Organizer: Tsukuba University symposium of advanced science
  • Invited
• [Presentation] Toward creating a mouse loyal to its partner. (2020)
  • Author(s): Qi Zhang
  • Organizer: The 43rd Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research / Invited
• [Presentation] The important roles of PIGA gene in brain development and epileptic encephalopathy revealed by tissue-specific knockout. (2020)
  • Author(s): Kandasamy LC, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young LJ, Zhang Q
  • Organizer: The 43rd Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research
• [Remarks] my lab webpage
  • URL: https://www.qizhanglab.com/
• [Funded Workshop] East/South East Asia Social Brain Symposium (2021)
• [Funded Workshop] The 43rd Annual Meeting of Japan Neuroscience Society (2020)