The roles of basolateral amygdala in regulation of optimism and pessimism

2021 Fiscal Year Annual Research Report

• Project/Area Number: 19K21807
• Research Institution: University of Tsukuba
• Principal Investigator: 張 王其 筑波大学, 人間系, 助教 (20525604)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: optimism and pessimism / neural circuit / basolateral amygdala / calcium imaging / fiber photometry

Outline of Annual Research Achievements

In this fiscal year, we successfully labelled BLA cells with calcium indicators and set up fiber photometry system. We recorded the activity dynamics of multiple populations of cells in basolateral amygdala during each step of ambiguous tone test. And we found that different BLA populations experienced distinct dynamics during the test. The data suggest that different populations of BLA cells regulate the direction of cognitive bias in different ways. We could publish 3 papers in international journals, and present our work in six international conferences.

Research Products

• [Journal Article] On the origins of social behavior diversity. (2021)
  • Author(s): Larry Young, Qi Zhang
  • Journal Title: The Japanese Journal of Animal Psychology Volume: 1 Pages: 1
  • DOI: 10.2502/janip.71.1.4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid - induced seizures in neuronal GPI anchor deficiency mouse models. (2021)
  • Author(s): Kandasamy L, Tsukamoto M, Banov V, Tsetsegee S, Nagasawa Y, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young L, Zhang Q
  • Journal Title: Human Molecular Genetics Volume: 30(9) Pages: 758-770
  • DOI: 10.1093/hmg/ddab052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The hippocampus encodes delay and value information during delay-discounting decision making. (2021)
  • Author(s): Masuda A, Sano C, Zhang Q, Goto H, McHugh T, Fujisawa S, Itohara S.
  • Journal Title: Elife Volume: 9 Pages: 52466
  • DOI: 10.7554/eLife.52466.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Oxytocin receptor and the diversity in social behaviors. (2021)
  • Author(s): Qi Zhang
  • Organizer: The Social Brain Symposium 2.0: Social Neuroscience in the Post Pandemic Era, Tsukuba Conference 2021
  • Int'l Joint Research / Invited
• [Presentation] On the origin of diversity in social behavior. (2021)
  • Author(s): Qi Zhang
  • Organizer: East/South East Asia Social Brain Symposium
  • Int'l Joint Research / Invited
• [Presentation] Inhibitory neurons play key roles in mediating multiple phenotypes in a mouse model of inherited glycosylphosphatidylinositol deficiency disease. (2021)
  • Author(s): Qi Zhang
  • Organizer: The 15th International Conference on Genetic Disorders and Gene Therapy
  • Int'l Joint Research / Invited
• [Presentation] Toward creating a mouse loyal to its partner. (2021)
  • Author(s): Qi Zhang
  • Organizer: The Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research / Invited
• [Presentation] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models. (2021)
  • Author(s): Kandasamy LC, Zhang Q
  • Organizer: The 44th Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research / Invited
• [Presentation] The trait-like differences in cognitive bias in outbred CD-1 mice. (2021)
  • Author(s): Tsetsegee S, Zhang Q
  • Organizer: The 44th Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research / Invited
• [Remarks] lab webpage
  • URL: https://www.qizhanglab.com/
• [Funded Workshop] The 44th Annual Meeting of Japan Neuroscience Society (2021)