Construction of active sites composed of multi-functional groups with precisely controlled distance by use of decomposition reaction

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K22074
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 27:Chemical engineering and related fields
• Research Institution: Hokkaido University
• Principal Investigator: Kamiya Yuichi 北海道大学, 地球環境科学研究院, 教授 (10374638)
• Co-Investigator(Kenkyū-buntansha): 大友 亮一 北海道大学, 地球環境科学研究院, 准教授 (10776462) ; 梅澤 大樹 北海道大学, 地球環境科学研究院, 准教授 (20503618)
• Project Period (FY): 2019-06-28 – 2021-03-31
• Keywords: 分解反応 / アミド化合物 / 酸塩基ペアサイト / 固定触媒

Outline of Final Research Achievements

Adjacent acid-base pair sites, which were consisted of carboxyl and amine groups, were constructed on silica surface by hydrolysis of an amide compound, which were anchored on the silica in advance. It was found that this catalyst showed extremely high catalytic activity for cross-aldol condensation of 4-nitrobenzaldehyde with acetone. The acid-base pair sites that were three methylene groups away from each other, which were constructed using an diamide compound that contains three methylene groups in the structure, showed less activity for the reaction that the catalyst with adjacent acid-base pair sites, demonstrating that the distance between acid and base functional groups was important factor for the reaction.

Free Research Field

触媒化学

Academic Significance and Societal Importance of the Research Achievements

精密にそれらの配置を制御して２つ以上の官能基を集積させた機能集積活性サイトは、高い触媒活性を示したり、高難度反応や多段反応を効率的に促進する可能性がある。本研究で得られた成果は、アミドの分解反応を利用することが鍵であり、隣接した酸点と塩基点からなるペアサイトを効率的かつ、その間の距離をメチレン基１つのレベルで制御できる触媒活性点の構築手法を提供するものである。この手法は、機能集積活性サイトの高次構造を精密に制御できる高い拡張性を持つ。