Design of nanostructures to control phothermal effect and phononics under multi-photon excitation conditions

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K22176
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields
• Research Institution: National Institute for Materials Science
• Principal Investigator: SHIRAHATA Naoto 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, グループリーダー (80421428)
• Project Period (FY): 2019-06-28 – 2021-03-31
• Keywords: バイオマーカー / 蛍光 / フォロサーマル効果 / 量子ドット / コロイダルナノ粒子 / 血漿タンパク質 / シリコン

Outline of Final Research Achievements

The purpose of this study was the colloidal synthesis of a water-soluble silicon quantum dot (SiQD) biomarker and develops the function of the photothermal effect expressed in the marker. First, we investigated the photothermal effect in SiQD, and found that the amount of heat generated in SiQD under sequential absorption of photons increases as the QD size increased. Second, when plasma protein was allowed to act on SiQD, we found that protein denaturation other than globulin was small. In addition, the cellular uptake of QD modified with a carboxyl group was small. As described above, the QD design guideline for preventing the uptake of QD into normal cells and conversely promoting the uptake into cancer cells has been clarified.

Free Research Field

ナノ粒子科学

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍等の治療において、セラノティクスの考え方が広く普及し発展が期待されるなか、
強い関心は生体内における該腫瘍等をリアルタイムに診察し、同時に、患者への身体的負担
を最小限に、該腫瘍等を選択的に死滅/除去させる治療システムの開発にある。がん細胞に特異的に結合する可能性を有し、一方で正常細胞には結合しない特異性を発現する生体に無毒なナノ粒子の合成開発に成功した。さらに当該ナノ粒子はフォトサーマル効果を発現した。