2021 Fiscal Year Final Research Report
Redox-neutral radical generation using a catalytic amount of titanium alkoxides
| Project/Area Number |
19K22182
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 33:Organic chemistry and related fields
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Keywords | 光反応化学 / 低原子価チタン |
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| Outline of Final Research Achievements |
By irradiating an alkoxytitanium complex with visible light, benzyl radicals are generated catalytically from benzyl alcohols using isopropyl alcohol as a hydrogen atom donor, and the benzyl radicals undergo dimerization in good yields. This reaction is a new type of reaction catalyzed by trivalent titanium species using inexpensive and easily handled alcohol as a hydrogen atom donor, instead of the conventional method using a stoichiometric metallic reductant, and it opens up new possibilities for synthetic organic reactions using trivalent titanium species.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、光照射下、入手容易なアルコールを水素原子供与体として用いることにより、活性種として有用な低原子価チタンの新しい触媒的発生法を実現したものである。低原子価チタン種は有用な一電子還元剤として広く利用可能であり、特に本反応ではさまざまに配位子の設計が行え、可視光エネルギーも利用可能であることから、今後廃棄物の少ないさまざまな物質合成に展開できるものと期待できる。
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