2023 Fiscal Year Final Research Report
Establishment of an all-complete chemical synthesis process producing 10 trillion peptide oligomers in one container.
| Project/Area Number |
19K22272
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 38:Agricultural chemistry and related fields
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Chiba Kazuhiro 東京農工大学, (連合)農学研究科(研究院), 学長 (20227325)
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| Project Period (FY) |
2019-06-28 – 2024-03-31
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| Keywords | 核酸医薬 / 電解合成 / 化学合成 / 中分子 |
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| Outline of Final Research Achievements |
The first amino acid is bound to a bead-shaped resin, and then amino acids are successively bound to the beads in sequence order (solid-phase synthesis). This method is widely used to synthesise specific target peptides as designed. In this study, we aim to establish a new liquid-phase synthesis method that utilises the advantages of the solid-phase synthesis method as an innovative chemical process that can accurately obtain all theoretical species as an equivalent mixture. To achieve this, a number of new challenges need to be overcome, and overcoming these challenges is a highly innovative research task that surpasses conventional technology.
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| Free Research Field |
生物有機化学
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| Academic Significance and Societal Importance of the Research Achievements |
．本研究は，これまでの方法の課題点を克服し，ほぼ無限に存在するペプチド分子について，体系的，網羅的，かつ定量的に完全化学合成を達成する革新的な提案である．本法を応用することにより、今後新たに発生する感染症対策や，新種の疾病，新規農薬用途などに対応した活性物質を探索するために極めて重要な役割をになう革新技術となるものである．
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