2022 Fiscal Year Final Research Report
Antiviral response induced by Toxoplasma latency: unraveling the attack and defense between protozoa and viruses.
| Project/Area Number |
19K22354
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 42:Veterinary medical science, animal science, and related fields
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
Xuan Xuenan 帯広畜産大学, 原虫病研究センター, 教授 (10292096)
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| Co-Investigator(Kenkyū-buntansha) |
正谷 達謄 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (70614072)
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| Project Period (FY) |
2019-06-28 – 2023-03-31
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| Keywords | トキソプラズマ / ウイルス / 免疫 |
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| Outline of Final Research Achievements |
The aim of this study was to clarify the effects of latent Toxoplasma infection on viral growth and virulence, and to elucidate which factors among the antiviral innate immune signals are activated in cells latently infected with Toxoplasma by using protozoa-virus co-infection experiments in cultured cells and laboratory animals. We conducted experiments to clarify which factors among the antiviral innate immune signals are activated in Toxoplasma latently infected cells. The results showed that the expression of innate immunity-related genes in the brains of mice latently infected with T. gondii increased, and stage-transformed T. gondii induced STAT1 phosphorylation and nuclear translocation in infected cells, and that mice latently infected with Toxoplasma became resistant to viral infection.
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| Free Research Field |
獣医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、トキソプラズマが誘導する抗ウイルス自然免疫誘導の一端を明らかにした。このように、一つの宿主をめぐって複数の病原体同士がせめぎ合う様子を明らかにすることで、実際に生体で起こっている感染症の本態を明らかにすることができると考えられる。トキソプラズマに潜伏感染した者は世界の全人口の1/3にのぼるとされており、最もありふれた原虫感染症といえる。すなわち、これまで基礎免疫学・感染症学で得られたSPFマウスへの病原体接種実験により得られた成果には、トキソプラズマのような潜伏感染病原体の影響を考慮していく必要があることを示唆する、
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