Roles of organelle contacts on PTSD onset during adult neurogenesis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K22415
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Hirabayashi Yusuke 東京大学, 大学院工学系研究科(工学部), 准教授 (80447391)
• Project Period (FY): 2019-06-28 – 2021-03-31
• Keywords: オルガネラ

Outline of Final Research Achievements

Post-traumatic stress disorder (PTSD) is a disorder caused by intense shock and stress, with an incidence rate of 5-8%. Thus, PTSD is a major social problem because it causes difficulties in daily life and sometimes triggers crime. However, although abnormalities in memory recall mechanisms have been proposed as a cause of PTSD, the molecular mechanisms remain largely unknown. In this study, we investigated the molecular causes of PTSD onset and obtained results that provide a clue to its elucidation.

Free Research Field

神経幹細胞

Academic Significance and Societal Importance of the Research Achievements

PTSDを罹患すると一般的な環境とPTSDの原因となった特定の状況を過剰に関連付けてしまい、安全な状況下でも恐怖を感じるようになる。例えば火事を原因とするPTSD患者は焚火と火事の匂いについて火の規模や危険性などの「差別化」が出来ず、焚火に必要以上の恐怖を感じることになる。本研究はこのような問題の解決の糸口を見出す重要な研究である。