2021 Fiscal Year Final Research Report
| Project/Area Number |
19K22479
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 47:Pharmaceutical sciences and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
TERUYA Kenta 東北大学, 医学系研究科, 准教授 (30372288)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Keywords | anti-prion / cellulose ether / drug / gmfb / preventive treatment / prion / T-cell |
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| Outline of Final Research Achievements |
We have found that cellulose ether, which is routinely ingested as a capsule and thickener for pharmaceuticals, has significant anti-prion activity in mice. In this study, we investigated what biological functions are involved in this unexpected effect. Investigations of brain proteins have identified a protein called glial maturation factor b, and investigations of cell types have identified several receptors on T cells as relevant candidates for the anti-prion activity.
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| Free Research Field |
プリオン病
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| Academic Significance and Societal Importance of the Research Achievements |
プリオン病をはじめとする神経変性疾患の実効的な治療手段が求められている。セルロースエーテルは、本来、生体不活性な化合物として日常生活に広く用いられているうえ、幾つかの特性は、プリオン病のような特殊な疾患に適している。抗プリオン活性に関与する応答などが見つかられは、プリオン病とはじめとする神経変性疾患に対抗する手段を提供できることとなる。
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