2021 Fiscal Year Final Research Report
Active autophagy that promotes cell proliferation via intracellular metabolic remodeling
| Project/Area Number |
19K22482
|
|---|
| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Medium-sized Section 47:Pharmaceutical sciences and related fields
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-06-28 – 2022-03-31
|
| Keywords | シグナル伝達 |
|---|
| Outline of Final Research Achievements |
Autophagy is widely accepted as a phenomenon that promotes degradation of intracellular proteins and organelles upon starvation stimulation. However, we have found that an inflammatory cytokine IL-1 induces autophagy independently of starvation. Because IL-1 activates the transcription factor NF-kB, we screened NF-kB target genes involved in starvation-independent autophagy. We identified a novel autophagy-inducing factor and named this factor as SIAIF (Starvation-independent autophagy-inducing factor). We found that SIAIF-mediated active autophagy promotes cell proliferation via inducing intracellular metabolic remodeling.
|
| Free Research Field |
分子生物学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究によって発見された新規オートファジー誘導因子は、がん細胞において高く発現しており、がん細胞の増殖を促進することが明らかとなった。従って、この因子を阻害することにより、がん細胞の増殖性を低下させ、がん組織を退縮させることができると期待される。すなわち、本研究成果はがんの新しい治療法開発につながる可能性があり、社会に貢献できると考えられる。
|
