2020 Fiscal Year Final Research Report
Role of Fusobacterium in colon cancer metastasis
| Project/Area Number |
19K22567
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 50:Oncology and related fields
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2019-06-28 – 2021-03-31
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| Keywords | 大腸がん / がん転移 |
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| Outline of Final Research Achievements |
Fusobacterium (FB) has attracted much attention in recent years due to its high amount of localized cancer in colorectal cancer patients. In our study, we found a loss of cell polarity when FB was added to organoid cultured cells, a three-dimensional culture of colorectal cancer. We have demonstrated by genetic and pathological analysis that this change causes EMT (Epithelial-Mesenchymal Transition /or Transformation), which leads colorectal cancer from scaffold-dependent polarized proliferation by basement membrane to invasion and metastasis. In addition, we have demonstrated that epithelial-mesenchymal transition/or transformation occurs in colon cancer. In a mouse model of cancer metastasis using colorectal cancer, the addition of FB accelerated the metastasis of the cancer.
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| Free Research Field |
消化器内科
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| Academic Significance and Societal Importance of the Research Achievements |
大腸がんの転移に細菌が関与するということはピロリ菌の発見のようなこれまでの常識を覆す画期的な研究となる可能性を秘めている。FBと大腸がんに関してはこれまで多くの論文では接着して増殖を促進して発がん過程の促進をするといった知見であったが、我々の仮説はFBはがんの転移にかかわる役割をしている点で既存の概念を変えるものであり極めて重要である
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