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2022 Fiscal Year Final Research Report

Why does alpha-ray therapy work? Approaching the question from the viewpoint of cancer immunity

Research Project

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Project/Area Number 19K22587
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 52:General internal medicine and related fields
Research InstitutionHokkaido University

Principal Investigator

Ogawa Mikako  北海道大学, 薬学研究院, 教授 (20344351)

Co-Investigator(Kenkyū-buntansha) 東川 桂  北海道大学, アイソトープ総合センター, 助教 (10756878)
Project Period (FY) 2019-06-28 – 2022-03-31
Keywordsα線 / 核医学治療 / がん免疫
Outline of Final Research Achievements

First, we examined cancer immunity induced by external irradiation with X-rays. The results suggest that external irradiation with X-rays temporarily reduces the activation of immunity in tumors, but subsequently induces the activation of cancer immunity. We synthesized At-211-labeled RGD peptides and examined cell death. We have previously shown that the At-211-labeled peptide releases more calreticulin upon immune activation than the I-131-labeled peptide. On the other hand, no correlation was observed between the amount of At-211 labeled material taken into cells and the amount of Calreticulin released. This may suggest that the At-211-labeled drug taken into the cell is not highly effective in disrupting the cell membrane.

Free Research Field

分子イメージング

Academic Significance and Societal Importance of the Research Achievements

α線核医学治療への期待が世界的に高まっている。これは、臨床で見られた治療効果の高さによるが、その理由がわかっていない。本研究では、がん免疫に着目しα線の治療効果について検証し、免疫賦活化の可能性を示した。さらに、At-211による標識薬剤の合成に成功し、今後のα線核医学治療の展開へ向けて一助になるものと考える。

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Published: 2024-01-30  

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