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2020 Fiscal Year Final Research Report

Development of drug delivery system using nano-micelle carrier targeting placenta complicated with preeclampsia

Research Project

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Project/Area Number 19K22678
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Fujii Tomoyuki  東京大学, 医学部附属病院, 届出研究員 (40209010)

Co-Investigator(Kenkyū-buntansha) 永松 健  東京大学, 医学部附属病院, 准教授 (60463858)
Project Period (FY) 2019-06-28 – 2021-03-31
Keywords妊娠 / ドラッグデリバリーシステム / 胎盤 / トロンボモジュリン
Outline of Final Research Achievements

This study aimed to develop a novel drug delivery system targeting the placenta focusing on PEGylated thrombomodulin (TM). From a variety of PEG-TM libraries, we identified a PEG-framed carrier with seven TM molecules attached to it as a structure with high placental integration without fetal transfer. When this PEG-TM was administered to a mouse model of preeclampsia, the improvement of the PE symptoms was observed with a smaller dose than with an administration of TM alone. This PEG-TM is expected to improve placental function by the protective effect of TM and at the same time, can enhance the pharmacological effect of the agent attached to PEG-TM.

Free Research Field

周産期医学

Academic Significance and Societal Importance of the Research Achievements

先行研究においてトロンボモジュリン(TM)はその血管保護作用、抗炎症作用により胎盤機能保護作用を発揮することが推定されていた。本研究では、そのTMのPEG化フレームによりTM同志の分子密度を高めることで胎児移行性がなく胎盤集積性が上昇するという知見をえた。PEG化TMに薬剤を搭載させて投与する場合に、より少量で胎盤集約的にその効果を発揮させることが可能となると推測された。胎盤機能障害を背景に生じる様々な周産期疾患の薬剤開発において、本研究により見出された技術は幅広い応用が期待できる。

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Published: 2022-01-27  

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