2020 Fiscal Year Final Research Report
Elucidation of mechanisms of regeneration of periodontal tissue by mathematical modelling
Project/Area Number |
19K22714
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 57:Oral science and related fields
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
北村 正博 大阪大学, 歯学研究科, 准教授 (10243247)
竹立 匡秀 大阪大学, 歯学部附属病院, 講師 (60452447)
Canela Andres 京都大学, 白眉センター, 特定准教授 (90837585)
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Project Period (FY) |
2019-06-28 – 2021-03-31
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Keywords | 歯周組織 / 再生機構 / 数理モデル |
Outline of Final Research Achievements |
Currently, various therapies for regeneration of periodontal tissue have been developed. However, the efficacy of the therapies depends on patients. If the factors affecting the efficacy of regeneration are understood and linked to the prediction of the rate of regeneration, it will be useful for proper selection of effective regenerative therapies or development of new regenerative therapies. Therefore, in this study, by introducing a mathematical modeling of regeneration of periodontal tissue, we attempted to comprehensively understand the molecular mechanisms of regeneration of periodontal tissue. Furthermore, by applying the mathematical model, we elucidated a mechanism of regeneration of periodontal tissue at a system level.
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Free Research Field |
口腔科学
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Academic Significance and Societal Importance of the Research Achievements |
本研究により構築した数理モデルを応用することで、将来的に、患者は確実性の高い再生治療法を選択できるようになります。加えて、現行の再生予後診断技術を大きく革新することが可能となります。さらに、実用的な再生効果予測技術は、開発中の歯周組織再生医療薬の効果や適切な処方を予測することにも利用できるため、新規歯周組織再生治療剤の開発促進や、再生医療産業の活性化にも繋がることが期待できます。
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