Discovery of Anisakis anthelmintic components and development of oral formulations that deliver them to Anisakis

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K22778
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 58:Society medicine, nursing, and related fields
• Research Institution: Hokkaido University of Science
• Principal Investigator: CHONO Sumio 北海道科学大学, 薬学部, 教授 (90347790)
• Co-Investigator(Kenkyū-buntansha): 戸上 紘平 北海道科学大学, 薬学部, 准教授 (20582357) ; 板垣 史郎 札幌医科大学, その他部局等, 准教授 (00360925)
• Project Period (FY): 2019-06-28 – 2023-03-31
• Keywords: アニサキス / 駆虫 / DDS

Outline of Final Research Achievements

In this study, Anisakis anthelmintic components were discovered, and several food additives showed anthelmintic effects. Oral formulations were designed and prepared to deliver food additives with anthelmintic effects to Anisakis. When oral formulations was administered to rats with gastric infection with Anisakis, 100% of Anisakis died just 1 hour after administration, and gastrointestinal damages was not observed due to administration of formulations. In summary, oral formulations that delivers anthelmintic components to gastrointestinal-infected Anisakis were developed, and their high anthelmintic efficacy has been demonstrated.

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

本研究で得られた成果と学理は、これまでにないDDSを基盤とする斬新さゆえ、アニサキス駆虫研究のあり方に一石を投じ、アニサキス食中毒の予防・治療にブレイクスルーをもたらすものである。医薬品に比べて上市へのハードルが低い食品添加物成分にアニサキス駆虫効果を見出し、それらを経口製剤化した点が本研究の大きな特徴かつ利点であり、実用面での社会的な意義は大きい。今後は、魚生食の直前や直後に予防的かつ気軽に摂取できる飲料等の製品開発を進める。