2020 Fiscal Year Final Research Report
Neural network for activation and inhibition of right frontal lobe function
| Project/Area Number |
19K22801
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中田 光俊 金沢大学, 医学系, 教授 (20334774)
木下 雅史 金沢大学, 医学系, 講師 (50525045)
篠原 治道 金沢大学, 医学系, 客員教授 (20135007)
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| Project Period (FY) |
2019-06-28 – 2021-03-31
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| Keywords | 右前頭葉 / 賦活 / 抑制 / ネットワーク / 覚醒下手術 / 画像統計解析 / 脳腫瘍 |
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| Outline of Final Research Achievements |
The purpose of this study is to reveal the neural networks involved in activation and inhibition of right frontal lobe functions. In this study, we used the techniques of awake surgery, statistical analysis of images, and fiber dissection to clarify the functions and regions of the brain involved in inhibition. We found following results: the medial prefrontal cortex and the orbitofrontal region of the inferior frontal gyrus were involved in the inhibition of emotional understanding, Zone II of the cingulate gyrus related to control of attention, and the posterior component of the frontal aslant tract was involved in the control of movement. Emotional recognition was markedly different due to damage to areas involved in inhibition. For attention and motor functions, damage to the inhibitory regions caused attention deficits and transient paralysis, respectively. The results of current study may be applicable to rehabilitation programs.
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| Free Research Field |
リハビリテーション科学
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| Academic Significance and Societal Importance of the Research Achievements |
従来の脳機能研究は，機能が賦活する領域を責任領域としてとらえてきた．本研究プロジェクトでは脳機能の賦活・抑制に関わる神経ネットワークを解明することを目的に，特に機能の抑制に関わる脳領域とその損傷により生じる症状に着目して研究を遂行した．本研究結果は従来の脳機能研究の概念にとって新しい考え方であり，学術的意義は高いと考える．また，機能の抑制に関わる領域を解明するために用いた手法は，他の様々な研究に応用可能である．さらに，本研究成果に基づいた新しいリハビリテーション治療概念を提唱できる可能性があり，社会的に意義ある研究成果であると考える．
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