Development of novel stroke-oriented nutrition science based on the regulation of neuroinflammation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K22813
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Kumamoto University
• Principal Investigator: Katsuki Hiroshi 熊本大学, 大学院生命科学研究部(薬), 教授 (40240733)
• Project Period (FY): 2019-06-28 – 2022-03-31
• Keywords: 脳神経疾患 / ビタミンA / レチノイド / トリプトファン / 神経保護 / 脳内炎症

Outline of Final Research Achievements

This study addressed the effects of metabolites of dietary vitamins and amino acids on the pathogenic events of intracerebral hemorrhage (ICH) in experimental animals. Results showed that supplementation of vitamin A ameliorated motor dysfunction associated with ICH. Mechanisms of neuroprotection and suppression of neuroinflammation by several vitamin A-related compounds were also revealed in this study. Additionally, a tryptophan metabolite was found to produce therapeutic effect on ICH.

Free Research Field

神経薬理学・健康科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、脳内炎症の制御に焦点を当てて食事由来成分の効果を明らかにすることで、脳疾患治療に最適化された栄養管理・強化補給法の確立に資することを目指した。脳内出血に対する食事性強化補給法の確立において重要となるビタミンおよびアミノ酸代謝物の効力の一端を明らかにしたことで、カロリー補給や体液平衡維持といった従来の栄養管理の枠組みを超えた新たな視点からの「脳卒中栄養学」の創出に寄与するものである。