2020 Fiscal Year Final Research Report
An experimental study on the theory of lymph node-mediated hematogenous metastasis
| Project/Area Number |
19K22941
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山口 匡 千葉大学, フロンティア医工学センター, 教授 (40334172)
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| Project Period (FY) |
2019-06-28 – 2021-03-31
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| Keywords | リンパ節転移 / 転移 / 解剖 / 血流欠損 |
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| Outline of Final Research Achievements |
This proposal is to experimentally verify the theory of lymph node-mediated hematogenous metastasis, which considers that the sentinel lymph node can be the origin of systemic metastasis. The results of this study can be summarized in the following two points. (1) A perfusion defect is formed in the early stage of lymph node metastasis. (2) The pathological images of lymph nodes in patients with head and neck cancer were carefully examined, and the presence of perforating branches penetrating the lymph node capsule was confirmed. The lymph node-mediated hematogenous metastasis theory accurately describes hematogenous metastasis in the early stage when tumor cells have metastasized and proliferated in the marginal sinuses of lymph nodes. In the future, it is necessary to accumulate experimental evidence for this theory.
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| Free Research Field |
医用システム
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は, 本理論が適用される転移リンパ節のステージを明らかにした. 本理論に基づきセンチネルリンパ節からの遠隔転移を予防するには, 原発巣が確認された段階で, 原発巣周囲に確認される全てのリンパ節に対して予防的治療を実施することが求められる. 本研究成果は, 本理論の学術的根拠ならびに転移初期段階にあるリンパ節の予防的治療の理論的根拠を提示するものである.
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