2021 Fiscal Year Final Research Report
High resolution photoacoustic microscopy for deep tissue imaging by using nonlinear responses induced with third near-infrared light
| Project/Area Number |
19K22961
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Osaka University (2020-2021)
Nagoya University (2019) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
新岡 宏彦 大阪大学, データビリティフロンティア機構, 特任准教授(常勤) (70552074)
山岡 禎久 佐賀大学, 理工学部, 准教授 (80405274)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Keywords | 深部イメージング / 光音響 / 生体窓 / 高空間分解能 |
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| Outline of Final Research Achievements |
We tackled developing a cellular level resolution and deep tissue imaging technique by using near infrared light in the optical tissue windows, nonlinear optical responses of lanthanide ions, and photoacoustic imaging technique. We confirmed that it is possible to induce photoacoustic signals with multiple lanthanide ions. We also achieved photoacoustic images with lanthanide ion samples. In addition, we also confirmed that, by using appropriate excitation power, nonlinear optical responses are achieved with lanthanide ions. These results indicated that the use of near infrared light in the optical tissue window and lanthanide ions for photoacoustic imaging has a great potential to realize high-resolution deep tissue imaging.
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| Free Research Field |
応用計測光学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、生体組織や生体内部の詳細な状況を可視化できる技術の実現に向け、光音響イメージング技術をベースとした内容で深部・高空間分解能イメージングの実現に向け見通しをたてることが出来るものである。第３の生体窓の光は未だ使用例が少なく、光学素子や光学プローブ分子などの面で現状は不利な点が多いが、近年の状況を鑑みれば近い将来、この点については大幅に状況が改善されるものと期待できる。第３の生体窓の光を積極的に活用する技術は、近い将来、生命科学や医学分野の様々な研究における深部解析を支える技術の一つになると期待できる。
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