2020 Fiscal Year Final Research Report
Pharmacological and Optogenetic Dissection of Inferentatial Decision Making
| Project/Area Number |
19K23377
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0110:Psychology and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2019-08-30 – 2021-03-31
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| Keywords | Associative learning / Pavlovian conditioning / Optogenetics / Memory engram / Fear conditioning |
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| Outline of Final Research Achievements |
After the end of my contract at Hokkaido University School of Medicine (Dpt. Neuropharmacology), my colleagues (Dr. Paul Craddock (Lille University, France) and Dr. Nathan Holmes (New South Wales University, Australia)) and I developed a new model of associative learning and memory based on neurophysiological evidence suggesting that disinhibitory brain mechanisms drive associative learning.
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| Free Research Field |
Behavioral and System Neuroscience
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| Academic Significance and Societal Importance of the Research Achievements |
Understanding mechanisms underlying associative learning is essential when investigating psychiatric diseases. The originality of our work is that it integrates our current understanding of neural disinhibitory mechanisms into a model of associative learning and memory.
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