Comprehensive Characterizations of Particulate Matters for Exposome Analysis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23587
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0402:Nano/micro science, applied condensed matter physics, applied physics and engineering, and related fields
• Research Institution: Nagoya University
• Principal Investigator: Shimada Taisuke 名古屋大学, 工学研究科, 助教 (00850140)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: エクスポソーム解析 / 粒子状物質 / 濃縮捕集 / ナノワイヤ / 単一微粒子センシング / マイクロポア / イオン選択性電極 / 集積化チップ

Outline of Final Research Achievements

Human beings are exposing to a mixture of airborne fine particles showing various properties such as size (<10 um), compositions (elemental carbons and organic/inorganic compounds) with different concentration, and exposure to them causes health damages reaching to increase mortality. Comprehensive detections and characterizations of exposed particles are highly required for understanding their impacts on ones’ health. However, conventional techniques are unable to match the requirements due to difficulties in particle characterizations and in applicability to the person level. This work aim to develop an analytical method to comprehensively characterize PMs’ size and composition via collection of particles into aqueous solution and followed-by single particle and ion detections.

Free Research Field

ナノバイオライフサイエンス

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、環境中微粒子を水薄膜内に濃縮捕集することで、イオン成分分析・単一微粒子分析を超高感度化し、それら分析法により環境中水溶性・非水溶性微粒子の特性情報を網羅的に取得するところにある。また、社会的意義として、個人レベルで異なる微粒子のエクスポソームを解析し、健康と環境の関係を明らかにすることで、環境を含めた予防医療の開拓とオーダーメイド医療の創出に資する波及効果を有する。