Research and development of temperature and position detection and heating techniques for hyperthermia using magnetic particles

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23597
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Tohoku University
• Principal Investigator: TON THAT Loi 東北大学, 工学研究科, 助教 (90844499)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 磁気ハイパーサーミア / 磁性ナノ粒子 / 位置検知 / 温度検知 / 定温加熱 / がん温熱療法 / 感温磁性体 / 機能性磁性ナノ粒子

Outline of Final Research Achievements

This project aims to develop a treatment system for magnetic hyperthermia, which is attracting worldwide attention as a next-generation of cancer treatment method. The results of this project are shown the following. (1) We succeeded in developing a simple automatic therapeutic temperature control system using PID. (2) We proposed a simple and rapid a localization method for magnetic particles injected in tumor region by using a figure-8 coil and its spatial linear scanning. (3) To develop high-performance magnetic particles suitable for magnetic hyperthermia, we newly synthesized magnetic iron oxide (Fe3O4) nanoparticles, then evaluated their heating efficiency using a lab-made prototype treatment system and their AC/DC magnetization using SQUID-VSM.

Free Research Field

複合領域

Academic Significance and Societal Importance of the Research Achievements

日本ではがんによって年間約37万人の尊い命が失われ、その治療技術の高度化は焦眉の急である。本研究では低コストの簡易型自動定温加熱治療システムの開発を行った。これは、磁気温熱療法の研究開発の進展に寄与し、年間約43兆円超えの医療費を削減できる可能性をもっている。また、本位置探索技術は磁気温熱療法のみならず、磁性ナノ微粒子を用いたセンチネルリンパ節生検等、他の医療分野にも活用可能であり、その波及効果は著しく広い。