Three-dimensional synthesized human placenta from an iPSC-derived organ bud transplant

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23605
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Kyushu University (2020); Kyoto University (2019)
• Principal Investigator: Sato Mai 九州大学, 大学病院, 助教 (70850238)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 胎盤機能再生 / iPS細胞 / 胎盤器官芽

Outline of Final Research Achievements

The prognosis of children with premature severe gestational hypertension and fetal growth failure caused by pathological placenta is poor. The applicant has been researching the regenerative medicine of placental function by artificial placenta transplantation for placental insufficiency. We were able to obtain successful cases. In the final year of the project, we were able to purchase a dedicated iPS culture, which we had been hoping to do for some time, and prepare the experimental environment. The results of the transplantation experiments on mice are expected to be published in recent years.

Free Research Field

周産期

Academic Significance and Societal Importance of the Research Achievements

臓器再生医療には立体的な臓器の原器(器官芽)を作成することが有用な手法であると報告され注目を集めている。本研究もTakebeらの既報と同様の手法を用いて胎盤器官芽を作成した。この手法が発表されてから、肝臓、腎臓、腸管、肺、心臓、脳など各種臓器の器官芽を用いた研究が報告されてきたが、胎盤での報告例はない。本研究で作成した胎盤器官芽は汎用性・再現性のある、より生体に近い機能的な胎盤組織培養系としても使用できる。胎盤機能再生にとどまらず、病因の解明や新規薬剤の開発にも応用できるなど、胎盤を対象とした研究が飛躍的に進むことが期待される革新的な研究であると考えられる。