2021 Fiscal Year Final Research Report
Brain-controlled neuroprosthetic for restoration of upper-limb function
Project/Area Number |
19K23606
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0403:Biomedical engineering and related fields
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2019-08-30 – 2022-03-31
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Keywords | brain-computer interface / neuroprosthetics / upper-limb / rehabilitation / neuroplasticity / neuromodulation |
Outline of Final Research Achievements |
We developed a brain-controlled functional electrical stimulation (FES) system to elucidate the underlying mechanisms of upper limb motor recovery using Hebbian learning. We first tested the brain-controlled FES system and demonstrated that FES rapidly induced corticospinal excitability modulation. We then compared brain-controlled FES using primary motor cortex (M1) with FES using premotor cortex. Our results showed that the M1-based intervention was superior in eliciting corticospinal modulation. In summary, we developed a brain FES system with an accuracy of over 85% using threshold and machine learning methods and tested it. Our results demonstrate that brain control FES can rapidly neuromodulate the excitability of the central nervous system.
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Free Research Field |
neuroprosthetics
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Academic Significance and Societal Importance of the Research Achievements |
Our research findings elucidated the underlying mechanisms implemented through brain-controlled FES. This can be used in neurorehabilitation practice to rapidly neuromodulate the central nervous system excitability, which could improve motor function after neurological injuries.
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