2020 Fiscal Year Final Research Report
Development of diagnostic method using iimpulse oscillometry system in chronic airway disease
| Project/Area Number |
19K23610
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-08-30 – 2021-03-31
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| Keywords | インパルスオシロメトリー / IOS / 気管支喘息 |
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| Outline of Final Research Achievements |
In this study, we investigated the relationship between the subtype classification of bronchial asthma (BA) by the impulse oscillometry system (IOS) and the therapeutic effect of inhaled corticosteroids(ICS).
The group of patients treated with fluticasone propionate (FP), mometasone furoate(MF), and budesonide (Bud) were divided into central predominant type, peripheral predominant type, and resistless type based on the IOS results.The treatment effects were assessed using the Asthma Health Questionnaire (AHQ) and the Asthma Control Test (ACT).As a result, in central predominant type the AHQ was higher in the MF group, and the ACT score was higher in the FP group.In peripheral predominant type, in the FP group the AHQ was high and the ACT score was low.
This study revealed that the particle size of ICS and IOS subtype classification are related to therapeutic effect in BA treatment, and IOS may be an effective tool in the selection of ICS and the evaluation of BA phenotype.
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| Free Research Field |
呼吸器内科
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| Academic Significance and Societal Importance of the Research Achievements |
BAの臨床的・病態生理的特性から亜型分類がされているが、病理学的特徴、臨床パターンあるいは治療に対する反応性など、強い相関は認められておらず、臨床的に有用な喘息の表現型分類が必要とされている。IOSは、喘息において炎症部位を特定できる臨床的に有用な検査法と考えられるが、今までの報告では、IOSは喘息コントロール状況の判定に有用とされるが、喘息におけるIOSは重要視されてこなかった。
本研究では、IOSを用いて喘息患者を炎症部位から３つの亜型に分類し、治療戦略として標的部位に応じて、粒子径に基づいたICSを選択することが可能となる可能性を示したことで、IOSの有用性を示すことができたと考える。
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