Realization of osteoporosis treatment using organic-inorganic composite particles with new structure and function

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23611
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Tokyo University of Science
• Principal Investigator: Komatsu Syuuhei 東京理科大学, 基礎工学部 材料工学科, 助教 (60843844)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 骨再生 / 骨粗鬆症治療 / 有機無機ハイブリッド材料

Outline of Final Research Achievements

In this study, we conducted an experiment for the purpose of "treatment of osteoporosis using novel carbonate apatite particles with a drug-encapsulating bone-inducing ability". The produced particles have a core-shell structure, the shell is composed of CO3Ap that dissolves and turns into bone, and the core is composed of biodegradable polymer. The shell could load a bone morphogenetic protein and the core load a hydrophobic low molecule drug. Furthermore, when osteoblasts were cultured in the presence of the prepared particles, the expression level of osteocalcin, which is a differentiation marker for bone cells, increased, and calcified nodules were confirmed. From the above, the produced particles can be expected to be applied to the treatment of osteoporosis.

Free Research Field

バイオマテリアル工学

Academic Significance and Societal Importance of the Research Achievements

骨粗鬆症は罹患すると、寝たきりになり、認知症発症の悪循環に陥り、患者のQOLを著しく低下させる重篤な疾患である。骨粗鬆症の治療材料には、薬物内包が可能、新生骨の形成を誘導できる能力、低侵襲性などの特徴を持つものが望ましい。本研究では、骨粗鬆症の治療のための薬物内包可能な骨誘導能を持つ新規炭酸アパタイト粒子を作製した。作製した粒子は、骨へのインジェクトが可能な大きさであり、粒子の内部と表面にそれぞれ薬物を担持することが可能であった。さらに骨芽細胞を骨細胞へと分化誘導できたことから、骨粗鬆症を治療できる材料として期待できる。