Scanning ion conductance microscopy with a multi-analytical system from imaging sequence

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23643
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0502:Inorganic/coordination chemistry, analytical chemistry, inorganic materials chemistry, energy-related chemistry, and related fields
• Research Institution: Tohoku University
• Principal Investigator: Ida Hiroki 東北大学, 学際科学フロンティア研究所, 助教 (80844422)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: SICM / 走査型イオンコンダクタンス顕微鏡 / 生細胞計測

Outline of Final Research Achievements

Scanning ion conductance microscopy (SICM) is one of the powerful measurement techniques for obtaining morphological variations on the cell membrane with nanoscale. The SICM can apply as non-invasive cell measurement from current drop caused by the block of the ionic flow through the tip of the SICM. In this work, we have developed a new SICM system which can obtain a number of additional information from imaging by analyzing the ion current.

Free Research Field

電気化学計測

Academic Significance and Societal Importance of the Research Achievements

SICMの性能が向上することで、今まで把握できなかった細胞現象を可視化することができる。そのため、これまで様々なグループが他の装置との融合や高速化などの装置改善を試みてきた。本研究では、従来主流であったハード面での改善とは異なるソフト面での改善を試み、従来の改良と並行して適用可能な装置改善を試みた。