Relationship between placenta derived parathyroid hormone-related protein in dairy cows and blood mineral concentrations in newborn calves

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23709
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0605:Veterinary medical science, animal science, and related fields
• Research Institution: Azabu University
• Principal Investigator: Kazama Kei 麻布大学, 獣医学部, 助教 (80845298)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 副甲状腺ホルモン関連タンパク質 / PTHrP / カルシウム感知受容体 / CaSR / 乳牛 / 胎盤 / 微量ミネラル / カルシウム

Outline of Final Research Achievements

Parathyroid hormone-related protein (PTHrP) is involved in the transport of calcium (Ca) in the placenta, but the role of PTHrP in the placenta of dairy cows remains unclear. In this study, we focused on the transport of minerals containing trace elements and investigated the role of PTHrP in the placenta of dairy cows. PTHrP and Ca were higher in blood of neonatal calves than in mother cows. In addition, there were correlation between PTHrP and Ca, cobalt, chromium, molybdenum in neonatal calves. The expression level of the PTHrP gene was high in the maternal placenta. From the above, it was speculated that PTHrP is involved in Ca trans port in the placenta of dairy cows, and that placenta-derived PTHrP also affects the metabolism of trace elements in neonatal calves.

Free Research Field

産業動物内科学

Academic Significance and Societal Importance of the Research Achievements

子牛の死亡は畜産業に大きな経済的損失をもたらすが、毎年数万頭に及ぶ子牛が死産や虚弱子で生後まもなく死亡してしまう。副甲状腺ホルモン関連タンパク質（PTHrP）は、胎盤においてカルシウム（Ca）輸送に関与することが知られている。本研究の結果から、新生子牛の血液中PTHrPとCa、コバルト、クロムとの間に負の相関が、モリブデンとの間に正の相関があった。さらに、乳牛の胎盤においてPTHrP遺伝子の発現が認められ、ミネラル輸送に関与すると考えられた。これらの結果から、健康な胎子が成長するために必要な胎盤におけるミネラル代謝にPTHrPが関与すると考えられた。