Analysis of the intracellular transport in plants

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K23723
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0701:Biology at molecular to cellular levels, and related fields
• Research Institution: Nagoya University
• Principal Investigator: Yamada Moe 名古屋大学, 理学研究科, 助教 (80848391)
• Project Period (FY): 2019-08-30 – 2023-03-31
• Keywords: ヒメツリガネゴケ / 細胞内輸送 / 先端成長 / 微小管

Outline of Final Research Achievements

Intracellular transport, the system that positions cellular materials in their proper locations in the cell, is driven by the cytoskeleton and motor proteins. However, the molecular mechanisms underlying intracellular transport in the plant cell remain obscure. In this study, we used the basal land plant, Physcomitrium patens, as a model system. Through comprehensive analysis of motor proteins, we identified kinesins that function during cell growth and mitotic cell division, and obtained mutants that exhibit phenotypes reminiscent of abnormal intracellular transport.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

細胞内で物質を適切な時期に適切な場所に配置させる細胞内輸送は細胞にとって必須機能の一つである。植物は進化の過程で独自の細胞内輸送システムを構築しており、動物細胞内で機能している輸送分子は植物ではあまり保存されていない。本研究における分子モーターの解析は、植物の独自の輸送システムを紐解く手がかりとなるものであり、さらなる責任分子の同定によって植物特異的な輸送システムの根幹に迫ることが可能になると考える。