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2020 Fiscal Year Final Research Report

Elucidation of a pathogenic mechanism of colitis-induced depression based on concept for brain-gut association

Research Project

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Project/Area Number 19K23808
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0801:Pharmaceutical sciences and related fields
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Takahashi Kohei  国際医療福祉大学, 薬学部, 助教 (90846411)

Project Period (FY) 2019-08-30 – 2021-03-31
Keywords行動薬理 / 脳腸相関 / 潰瘍性大腸炎 / うつ病 / 神経炎症
Outline of Final Research Achievements

The purpose of this study is elucidation of a pathogenic mechanism of colitis-induced depression based on concept for brain-gut association to establish animal model of colitis with depression. As a result, we revealed that dextran sulfate sodium treated mice have validity of colitis with depression. Moreover, we found that intestinal-derived inflammatory cytokines affected the pathogenesis of colitis-induced depression. From these results, we suggested that the improvement of intestinal environment was an important for the therapy of colitis-induced depression.

Free Research Field

薬理学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果より、デキストラン硫酸ナトリウム処置マウスがうつ病を併発した潰瘍性大腸炎モデル動物として予測的並びに構成概念妥当性を満たしていることが示唆された。また、潰瘍性大腸炎に併発するうつ病の発症には腸由来の炎症性サイトカインの影響が大きく、腸内環境の改善が潰瘍性大腸炎に併発したうつ病の治療において重要であることが示された。これらの研究結果はこれまでに報告がなく、学術的並びに社会的に意義のある点だと考える。脳腸相関の概念に基づいた潰瘍性大腸炎併発性うつ病に対する新規治療法の開発が期待される。

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Published: 2022-01-27  

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