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2020 Fiscal Year Final Research Report

Epigenetic regulation of T cell senescence

Research Project

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Project/Area Number 19K23850
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0803:Pathology, infection/immunology, and related fields
Research InstitutionKeio University

Principal Investigator

Nagai Nao  慶應義塾大学, 医学部(信濃町), 特任助教 (80828145)

Project Period (FY) 2019-08-30 – 2021-03-31
KeywordsT細胞 / 疲弊 / 老化 / エピジェネティクス / 転写制御 / がん
Outline of Final Research Achievements

It has been widely recognized that T cells, which play a central role in the immune system, become dysfunctional with aging and diseases (termed “senescence” and “exhaustion”, respectively). In this study, we analyzed this mechanism using advanced technologies such as next-generation sequencers and bioinformatics. As a result, we found one candidate gene that is involved in exhaustion of CD8-positive T cells, which are responsible for anti-tumor immunity, in tumors.

Free Research Field

腫瘍微小環境

Academic Significance and Societal Importance of the Research Achievements

加齢に伴うT細胞の老化は、易感染性やワクチンに対する応答性の低下を引き起こす。また、がんにおけるT細胞の疲弊は、抗腫瘍免疫の低下による腫瘍の進展に関わる。T細胞の疲弊に関わる候補遺伝子を発見したことは、新規のがん免疫療法を開発したり、昨今注目を浴びる免疫チェックポイント阻害剤の治療効果を最大化する戦略を開発したりすることに結びつく。また、この遺伝子が老化と疲弊に共通して重要である場合には、加齢に伴う免疫応答の低下に対する予防・治療方法の開発にもつながる。

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Published: 2022-01-27  

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