Development of genomic prognostic model for angioimmunoblastic T-cell lymphoma and related diseases

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23879
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: University of Tsukuba
• Principal Investigator: Suehara Yasuhito 筑波大学, 附属病院, 病院助教 (90844811)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 血管免疫芽球性T細胞リンパ腫 / 末梢性T細胞リンパ腫, 非特定型 / 全エクソームシーケンス解析 / IDH2変異 / 5番染色体増幅 / TET2複数変異

Outline of Final Research Achievements

We performed whole exome sequencing analysis on a total of 145 cases of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, unspecified (PTCL-NOS) to integrate genomic aberrations and clinical information. We found that genomic abnormalities such as chromosome 5 amplification and IDH2 mutation are likely to coexist and are poor prognostic factors for AITL. We also found that the presence of multiple TET2 mutations was a poor prognostic factor.

Free Research Field

悪性リンパ腫

Academic Significance and Societal Importance of the Research Achievements

血管免疫芽球性T細胞リンパ腫は一般に予後不良の疾患であるが、長期生存が得られる例もあり、異質性のある疾患である。今回同定した亜分類に基づく標的治療の開発や、予後因子の有無に応じた治療戦略の層別化に繋がっていくと考えられる。