Identification of metastasis-related genes by analyzing genes in captured circulating tumor cells

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23881
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Ishibashi Rei 東京大学, 医学部附属病院, 助教 (50843299)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 血中循環腫瘍細胞

Outline of Final Research Achievements

Recent progress in the cancer systemic therapy has made it possible to chooose appropriate therapeutics dependin on the gene mutation signature of the cancer tissues. Becasue of this trend, frequent and conventional acquirement methods of cancer cells are needed. In this study, custom methods to acquire CTCs conventionally have been developed. Using this method, we can acquire cancer cells with minimum invasion and we could detect gene mutations in the cancer cells, which may opne a new avenue to choose appropriate therapeutics.

Free Research Field

大腸癌研究

Academic Significance and Societal Importance of the Research Achievements

本研究成果によって、これまで体に負担がかかっていたがん組織の採取が、血液から行えるようになり、小さい負担で効果的な治療法を選択することが可能となる。血中を循環する癌細胞の正常を詳しく調べることで血行性転移に関わる遺伝子等、新たな治療標的の同定も可能となる。