Elucidation of novel tumor blood vessel formation mechanism induced by myeloid cells

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23885
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: Osaka University
• Principal Investigator: Hayashi Yumiko 大阪大学, 微生物病研究所, 特任研究員 (00844127)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 腫瘍血管 / 生体イメージング / 血管新生阻害

Outline of Final Research Achievements

In this study, we focused on the dynamic changes of tumor blood vessels and myeloid cells to clarify the mechanism of resistance to anti angiogenic therapy. We constructed a biological imaging analysis system. Using this system, it has become possible to observe changes in tumor structure over time in a state closer to the living body. In addition, the localization of mature tumor blood vessels and changes in blood vessel density were observed by administration of angiogenesis inhibitors. Furthermore, the accumulation of myeloid cells in the tumor tissue was observed over time in the vicinity of the morphological change of blood vessels. These results suggest that myeloid cells are involved in blood vessel formation in tumors that are resistant to angiogenesis inhibitors.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

血管新生阻害剤に耐性を示すメカニズムを明らかにすることで、がん治療へのアプローチを再検討することができる。従来の解析方法では、経時的な観察を行っても同一個体の解析が難しいため個体差が大きく、腫瘍内で本当に起きている現象を捉えているとは言い難い。本研究で構築した腫瘍組織内の血管と骨髄系細胞の生体イメージング解析を用いた細胞間相互作用を検討することで、新たながん治療法の開発に繋がることが期待される。