2020 Fiscal Year Final Research Report
Analysis of each subset of CIML NK cells and development of new therapy for gastric cancer
Project/Area Number |
19K23892
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0901:Oncology and related fields
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Research Institution | Sapporo Medical University |
Principal Investigator |
Kubo Tomohiro 札幌医科大学, 医学部, 助教 (00634669)
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Project Period (FY) |
2019-08-30 – 2021-03-31
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Keywords | NK細胞 / 免疫療法 |
Outline of Final Research Achievements |
NK cells are transformed into Cytokine-induced-memory-like(CIML) NK cells by stimulating with multiple cytokines. And they have a strong cytotoxic effect.The function of subsets of CIML NK cells and the effect on solid tumors are unknown. In this study, we evaluated the expression of NK cell receptors in each subset of CIML NK cells. There was no significant difference in NK cell receptor expression between each subset. It was suggested that both subsets has strong cytotoxic activity.We also evaluated the cytotoxic activity against gastric cancer cell lines. It was revealed that the cytotoxic activity of CIML NK cells against gastric cancer cell lines was significantly higher than that of natural NK cells.
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Free Research Field |
免疫療法
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Academic Significance and Societal Importance of the Research Achievements |
CIML NK 細胞はの両サブセット共にインターロイキンにより効果的に刺激され、同等の強力な細胞傷害活性を有するとが推察された。さらにCIML NK 細胞は固型癌である胃癌細胞株に対しても既報で示された白血病細胞株と同程度の強力な細胞傷害活性を有し、高いサイトカイン産生能を有することを証明し、胃癌の新たな治療戦略の一つとなる可能性があることを見出した。
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