Establisment of Patient derived tumor orthotopic xenograft mouse model in biliary carcinoma

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23914
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0901:Oncology and related fields
• Research Institution: Fujita Health University
• Principal Investigator: Yoshikawa Junichi 藤田医科大学, 医学部, 助教 (40841185)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 患者腫瘍同所移植マウスモデル / 胆道癌

Outline of Final Research Achievements

The Patient Derived tumor Orthotopic Xenograft (PDOX) mouse model is a model in which a patient tumor is orthotopically transplanted into a mouse. A PDOX mouse model of biliary cancer has not been developed due to technical problems. The purpose of this study was to develop a PDOX mouse model of biliary cancer. When human biliary cancer was transplanted into the gallbladder of immunodeficient mice, it was relatively easy to carry out and a high tumor engraftment rate was observed. In creating a PDOX mouse model for biliary cancer, a model for transplantation into the gallbladder was considered to be an option to solve technical problems.

Free Research Field

胆道癌

Academic Significance and Societal Importance of the Research Achievements

PDOXマウスモデルは新規治療法開発や患者の個別化医療に最適な動物モデルとして近年注目されているモデルである。ほとんどの悪性腫瘍でPDOXマウスモデルが確立されているが、胆道癌のPDOXマウスモデルは未開発である。本研究では胆道癌のPDOXマウスモデルとして用いることができる可能性がある胆嚢への移植モデルを開発した。本モデルは胆道癌における新規治療法開発や患者の個別化医療への貢献が期待される。