Development of treatment for radiation injury using Muse cells

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K23935
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Hirosaki University (2020); Tohoku University (2019)
• Principal Investigator: Fujishima Yohei 弘前大学, 被ばく医療総合研究所, 助教 (80846684)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: 多能性幹細胞 / Muse細胞 / 放射線障害

Outline of Final Research Achievements

Since Muse cells could not differentiate into stem cells such as bone marrow stem cells, this research was conducted to make Muse cells more undifferentiated. Under hypoxia and nutrient starvation, the SSEA-3 positive rate of Muse cells decreased. It became clear that mesenchymal stem cells (MSCs) and Muse cells have the ability to change interchangeably with each other, although the proportion of Muse cells in MSCs may remain constant. These results suggest that Muse cells are not different cells from MSCs, but cells with altered MSCs, and Muse cells are cells equivalent to or "differentiated" from MSCs.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では、Muse細胞を未分化にするための基礎的研究として、Muse細胞に及ぼす低酸素と低栄養の影響を明らかにすることと、Muse細胞とMSCとの関係を解析することを目的とした。研究の結果、間葉系幹細胞（MSC）とMuse細胞は互いに互換的に変化する能力を有していることや、MSC中のMuse細胞の割合は一定に保たれている可能性があることを明らかにした点で意義がある。今後、MSCをより未分化に変化させることにより、より臨床的に有用な細胞を作ることが期待される。