The role of Neuropeptide Y in pathophysiology PCOS follicular development failure

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24045
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Urata Yoko 東京大学, 医学部附属病院, 助教 (20572598)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: Neuropeptide Y / 多嚢胞性卵巣症候群 / 卵胞発育障害

Outline of Final Research Achievements

<Objectives> PCOS accounts for 80% of anovulatory infertile women, but the pathophysiology of its follicular developmental disorders has not been elucidated and there is no specific treatment method. Neuropeptide Y (NPY), a neuropeptide, is known to have high blood levels in non-obese PCOS women, and NPY may be involved in PCOS. The objective of this study is to clarify (1) the mechanism of regulation of NPY and NPY receptor expression in the PCOS ovary, and (2) the function of NPY in the PCOS ovary. <Result>1.Androgen stimulation did not change NPY and NPY receptor expression in rodent granulosa cells. 2.Chronic androgen stimulation changed the expression of NPY and NPY receptors in rodent granulosa cells.3.Rodent granulosa cells administered with chronic DHT were stimulated with acute NPY, and apoptosis and cell proliferation ability were evaluated. The pattern of apoptosis changed with and without DHT administration.4.NPY concentration of human follicular fluid is under analysis.

Free Research Field

産婦人科学

Academic Significance and Societal Importance of the Research Achievements

Neuropeptide Yが多嚢胞性卵巣症候群の卵胞発育障害治療における、新規ターゲット分子の可能性が示唆された。