Development of microRNA-655 as a marker of tumour invasive potential in oral squamous cell carcinoma.

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K24061
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Harazono Yosuke 東京医科歯科大学, 東京医科歯科大学病院, 助教 (90845364)
• Project Period (FY): 2019-08-30 – 2024-03-31
• Keywords: microRNA / 口腔がん / EMT

Outline of Final Research Achievements

The aim of this study was to adapt microRNA-655, previously identified by the author as a marker of epithelial-mesenchymal transition (EMT), for clinical application in oral squamous cell carcinoma (OSCC) by measuring its levels in serum. Although the author had previously demonstrated the efficacy of miR-655 in various cell lines, primarily pancreatic cancer, its introduction into an oral cancer cell line to evaluate its EMT suppressive potential did not yield supportive results. Furthermore, the expression of microRNA-655 was measured in the serum of OSCC patients, with clinical data obtained from the Disease Bioresource Centre at Tokyo Medical and Dental University. However, no significant correlations were found between miR-655 expression and clinical parameters.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

膵臓がん細胞株や食道扁平上皮癌においてEMTマーカーとして立証されたmicorRNA-655は、口腔扁平上皮癌細胞株や口腔源平上皮癌においては、EMTマーカーとしての適応や予後との相関はみられなかった。