Effects of novel regenerative treatment for ligature-induced Periimplantitis with fibroblast growth factor-2.

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24063
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Fukuba Shunsuke 東京医科歯科大学, 歯学部附属病院, 医員 (50845625)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: インプラント周囲炎 / FGF-2 / 歯周治療学 / 顎堤保存術 / 分極化 / 骨補填材 / 人工骨

Outline of Final Research Achievements

A buccal dehiscence model around the implant in dogs was surgically created to evaluate the bone formation potential as the conventional treatment using Enamel matrix derivative (EMD) with xenograft, and its efficacy was reported. In order to compare EMD and Fibroblast growth factor-2(FGF-2), a buccal dehiscence model in dogs was surgically created to evaluate the bone formation potential of concomitant use of FGF-2 and β-TCP was evaluated, and its efficacy was reported. As for improving the potential of available alloplastic bone graft materials; β-TCP, it was reported that polarization of β-TCP promoted the bone formation. A comprehensive analysis was performed to search for the optimal alloplastic bone products for the peri-implantitis treatment. Unfortunately, it has not been possible to verify the efficacy of FGF-2 on peri-implantitis.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

近年、歯科インプラントが広く用いられるようになったのに伴い、インプラント周囲炎の報告が増えている。インプラント周囲炎は歯周炎と類似した臨床症状を呈するにも関わらず、歯周炎で有効な効果が得られた治療を行っても、必ずしも良好な結果が得られておらず、新規治療法の開発が喫緊の課題である。本研究では、インプラント周囲へのエナメルマトリックスタンパクと異種骨の併用の有効性や、新しい材料として荷電したバイオセラミックスの有効性、市場で入手可能な人工骨の網羅的な解析を通じて、今後のインプラント周囲炎治療に対するアプローチに関する研究において一助となると考えられる。