Sulfated vizantin leads biofilm detachment by affecting bacterial adhesion.

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K24087
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Niigata University
• Principal Investigator: Hasegawa Taisuke 新潟大学, 医歯学総合病院, 医員 (80844472)
• Project Period (FY): 2019-08-30 – 2021-03-31
• Keywords: バイオフィルム / ビザンチン / 初期付着菌群 / 菌体表面性状 / 付着関連遺伝子

Outline of Final Research Achievements

We verified the anti-biofilm effect of vizantin which was synthesized from diphtheria surface glycolipid (TDCM) as a lead compound. It causes detachment of Streptococcus mutans biofilm without affecting bacteria viability.
On hydroxyapatite (HA) discs coated by vizantin, bacterial adhesion to HA surface by early colonizer was suppressed. Because bacteria cell surface properties were changed non-specifically without affecting the growth of the bacteria, the gene expressions in relation to bacterial adhesion were changed in the presence of vizantin.

Free Research Field

う蝕学分野

Academic Significance and Societal Importance of the Research Achievements

本研究は、抗菌成分に頼らない口腔バイオフィルム制御法開発の一環であり、化学的制御法の弊害を減少させるとともに、口腔バイオフィルムを易剥離性とすることで、口腔ケアの省力化に貢献できると考えられる。近年では要介護者を支える家族や介助者の負担が増加しており、口腔ケアの省力化実現の可能性は、支える人の心身の負担軽減に寄与し得ると考えられる。