2022 Fiscal Year Final Research Report
Muscle regeneration using an injectable scaffold
| Project/Area Number |
19K24089
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
0907:Oral science and related fields
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-08-30 – 2023-03-31
|
| Keywords | 注入 / 筋再生 / ゼラチンハイドロゲル |
|---|
| Outline of Final Research Achievements |
The purpose of this study was to regenerate muscle tissue using a scaffold material that can be injected into the tissue. Local injection of adipose stem cell aggregates (ASCs) together with gelatin hydrogel microparticles containing cell growth factors such as polycrystalline plasma (PRP) improves the local engraftment rate of ASCs. In addition, local injection of hydrogel impregnated with PDGF-BB, which is the most useful for muscle regeneration in PRP, with ASCs to the leg of mice and applying muscle load promotes muscle regeneration. PDGF-BB-containing gelatin hydrogel microparticles are scaffolds that can be applied topically, and have been shown to be useful for local muscle regeneration.
|
| Free Research Field |
再生医療
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究は組織内に注入可能な足場材を用いた筋組織の再生を目的とした。脂肪幹細胞凝集体（ASCｓ）をPDGF-BBを含浸させたハイドロゲルと共に局所投与し、筋負荷を与えることで、筋再生が促進されることが明らかとなった。この技術はにより筋組織再生の選択の幅が広がり、患者の生活の質向上に貢献できると考えている。
|
