2020 Fiscal Year Final Research Report
Developing a new strategy for IgG4 related disease focusing on MARCO
| Project/Area Number |
19K24097
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
0907:Oral science and related fields
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-08-30 – 2021-03-31
|
| Keywords | IgG4関連涙腺・唾液腺炎 / MARCO / 自然免疫 |
|---|
| Outline of Final Research Achievements |
To clarify the role of M2 macrophage on pathogenesis of IgG4-RD, we planed to extract M2 macrophage from IgG4-DS patients and analyze them using DNA microarray. We successfully extract from health patients sample by now. On the other hand, we underwent genome enhancer analysis and find out KAT2B(PCAF) related with innate immunity. A more thorough understanding of the role of marco+M2 macrophages in IgG4‐RD could lead to the establishment of a mouse model of IgG4‐RD and to the eventual development of novel pharmacologic strategies.
|
| Free Research Field |
唾液腺疾患
|
| Academic Significance and Societal Importance of the Research Achievements |
これまでの研究で明らかになっているMARCOを介した下流シグナルを解析することで、MARCO-Tgマウスが作成でき、IgG4-RDの病態を反映することができれば、現在難航しているIgG4-RDモデルマウスの確立にもつながり、現在第一選択薬であるステロイドに代わる新しい分子標的治療にも繋がることが多いに期待される。
|
